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KMID : 1034720180100020115
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Journal of Neurosonology and Neuroimaging
2018 Volume.10 No. 2 p.115 ~ p.121
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Age-Related Spatial Distribution of Cerebral Microbleeds in Patients with CADASIL
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Lee Jung-Seok
Ko Keun-Hyuk
Oh Jung-Hwan
Park Joon-Hyuk
Lee Ho-Kyu
Kim Joong-Goo
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Abstract
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Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common genetic disorder causing stroke. Cerebral microbleeds (CMB) are known to be associated with CADASIL. In this study, we investigated the spatial distribution of CMB in different age groups and also elucidated the age-related spatial distribution of CMB according to the presence or absence of hypertension in patients with CADASIL.
Methods: Ninety-four patients with genetically conf irmed CADASIL and the R544C, R578C, R75P, and C452A mutations were investigated. The patients were divided into three groups according to age: <60 years (n=37), 60-69 years (n=24), and ≥70 years (n=33). The location of the CMB was classified as deep, lobar, or infra-tentorial.
Results: The patients aged <60 years had a significantly higher rate of hypercholesterolemia, a lower rate of hypertension, and a lower rate of use of antiplatelet agents than the patients aged ≥60 years. The group aged ≥70 years had significant more lobar CMB than the group aged <60 years. However, there was no significant difference in the number of patients with lobar CMB between the hypertensive subgroup aged ≥60 years and the hypertensive subgroup aged <60 years. There was no signif icant difference in the numbers of deep or infra-tentorial CMB among the three age groups.
Conclusion: In this study, there was a significant increase in lobar CMB in elderly patients with CADASIL.
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KEYWORD
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CADASIL, Magnetic resonance imaging, Intracranial hemorrhages, Hypertension
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